杰利（艾伦史瓦兹）是个可爱活的小胖子，今年暑假他被迫参加专门减肥的夏令营。然而营区的主人汤尼（班史帝勒）却是个行为怪异的坏蛋，百般折磨这群超重量级的小胖子，于是杰利呼朋引伴组成强大的胖子部队手对抗汤尼；但身手俐落的汤尼早已布下了重重陷阱，等待这群胖小虫的到来···

The Muppets are back in a new zany comedy, Muppets from Space. The Muppets embark on a hilarious extra terrestrial adventure in hopes of finding out about Gonzo's family members are aliens from a distant planet!　　Gonzo then gets a message that his relatives are coming for a visit, from outer space! But when word gets out on Miss Piggy's talk show, UFO Mania, that the friendly aliens are coming, a secret government agency led by K. Edgar Singer (Jeffrey Tambor) captures Gonzo and goes to great lengths to learn when his extra-terrestrial family will arrive.　　Now only the Muppets, led by Kermit and Miss Piggy, can save Gonzo and make the world safe for a friendly alien invasion!